We have developed a novel (patent pending) electric field measurement technology called Electric Field Encephalography (EFEG) for brain signal monitoring. NeuroFieldz technology is comprised of a system of high density array of sensors for measuring and analyzing the electric fields generated by the brain arising from intrinsic activity or external stimuli. The EFEG brain monitoring technique is a new modality that has several advantages over the current modalities, electroencephalography EEG (which measures the electric potential on the scalp) and magnetoencephalography MEG (which measures the magnetic field). Compared with MEG, EFEG has higher spatial resolution, is unaffected by stray magnetic fields, and does not require expensive bulky cryogenic equipment, thus making it field-deployable. Compared with EEG, EFEGTM is reference-less, has higher spatial resolution, leads to increased number of uncorrelated signals, and improves source reconstruction precision.  EFEG also provides dynamical information on millisecond time scales which is much faster than fMRI. The accurate source localization provided by EFEG will be of immense benefit in analyzing and localizing neurological signals (e.g. epileptic), as well as understanding the brains response to external stimuli

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Baldwin, Paige; Sridhar, Srinivas; Singh, Bijay

Nanoencapsulated combination drug formulations Miscellaneous

2023, (US Patent 11,648,211).

Tags: Nanomedicine

Yang, Shicheng; Green, Allen; Brown, Needa; Robinson, Alexis; Senat, Merline; Testino, Bryanna; Dinulescu, Daniela M; Sridhar, Srinivas

Sustained delivery of PARP inhibitor Talazoparib for the treatment of BRCA-deficient ovarian cancer Journal Article

In: Frontiers in Oncology, vol. 13, pp. 1175617, 2023.

Tags: Nanomedicine

Kunjachan, Sijumon; Detappe, Alexandre; Kumar, Rajiv; Ireland, Thomas; Cameron, Lisa; Biancur, Douglas E; Motto-Ros, Vincent; Sancey, Lucie; Sridhar, Srinivas; Makrigiorgos, G Mike; others,

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy (Retraction of Vol 15, Pg 7488, 2015) Miscellaneous

2022.

Tags: Nanomedicine

Thong, Phan Quoc; Huong, Le Thi Thu; Tu, Nguyen Dac; Nhung, Hoang Thi My; Khanh, Lam; Manh, Do Hung; Nam, Pham Hong; Phuc, Nguyen Xuan; Alonso, Javier; Qiao, Ju; others,

Multifunctional nanocarriers of Fe3O4@ PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery Journal Article

In: Nanomedicine, no. 0, 2022.

Tags: Nanomedicine

Rodell, Christopher B; Baldwin, Paige; Fernandez, Bianca; Weissleder, Ralph; Sridhar, Srinivas; Dubach, John Matthew

Quantification of cellular drug biodistribution addresses challenges in evaluating in vitro and in vivo encapsulated drug delivery Journal Article

In: Advanced therapeutics, vol. 4, no. 3, pp. 2000125, 2021.

Tags: Nanomedicine

Zhang, Di; Singh, Bijay; Moerland, Jessica; Mitchell, Owen; Lockwood, Lizbeth; Carapellucci, Sarah; Sridhar, Srinivas; Liby, Karen T

Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in BRCA1-deficient mice Journal Article

In: Scientific Reports, vol. 11, no. 1, pp. 1234, 2021.

Tags: Nanomedicine

Yang, Shicheng; Wallach, Mia; Krishna, Apurva; Kurmasheva, Raushan; Sridhar, Srinivas

Recent developments in nanomedicine for pediatric cancer Journal Article

In: Journal of Clinical Medicine, vol. 10, no. 7, pp. 1437, 2021.

Tags: Nanomedicine

Wilfred, NGWA; Kumar, Rajiv; Makrigiorgos, Gerassimos; Sridhar, Srinivas; Dougan, Stephanie

Biomaterials for combined radiotherapy and immunotherapy of cancer Miscellaneous

2020, (US Patent 10,835,604).

Tags: Nanomedicine

Cheng, Ming J; Mitra, Ronodeep; Okorafor, Chinedu C; Nersesyan, Alina A; Harding, Ian C; Bal, Nandita N; Kumar, Rajiv; Jo, Hanjoong; Sridhar, Srinivas; Ebong, Eno E

Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity Journal Article

In: Annals of Biomedical Engineering, pp. 1–14, 2020.

Abstract | Tags: Nanomedicine

Mitra, Ronodeep; Qiao, Ju; Madhavan, Sudharsan; O’Neil, Gerard; Ritchie, Bailey; Kulkarni, Praveen; Sridhar, Srinivas; Ven, Anne; Cherry, Erica; Ferris, Craig; others,

High fat diet versus disturbed blood flow conditions: Implications for endothelial glycocalyx integrity and pre-atherosclerotic inflammation Journal Article

In: The FASEB Journal, vol. 34, no. S1, pp. 1–1, 2020.

Tags: Nanomedicine

Schuemann, Jan; Bagley, Alexander F; Berbeco, Ross; Bromma, Kyle; Butterworth, Karl T; Byrne, Hilary L; Chithrani, B Devika; Cho, Sang Hyun; Cook, Jason R; Favaudon, Vincent; others,

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions Journal Article

In: Physics in Medicine & Biology, vol. 65, no. 21, pp. 21RM02, 2020.

Tags: Nanomedicine

Virani, Needa A; Kelada, Olivia J; Kunjachan, Sijumon; Detappe, Alexandre; Kwon, Jihun; Hayashi, Jennifer; Vazquez-Pagan, Ana; Biancur, Douglas E; Ireland, Thomas; Kumar, Rajiv; others,

Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption Journal Article

In: Plos one, vol. 15, no. 7, pp. e0236245, 2020.

Tags: Nanomedicine

Mueller, Romy; Yasmin-Karim, Sayeda; DeCosmo, Kaylie; Vazquez-Pagan, Ana; Sridhar, Srinivas; Kozono, David; Hesser, Juergen; Ngwa, Wilfred

Increased carcinoembryonic antigen expression on the surface of lung cancer cells using gold nanoparticles during radiotherapy Journal Article

In: Physica Medica, vol. 76, pp. 236–242, 2020.

Tags: Nanomedicine

Zhang, Di; Singh, Bijay; Moerland, Jessica; Mitchell, Owen; Lockwood, Lizbeth; Carapellucci, Sarah; Sridhar, Srinivas; Liby, Karen

Localized delivery of the PARP inhibitor Talazoparib for chemoprevention of breast cancer Journal Article

In: Cancer Research, vol. 80, no. 16_Supplement, pp. 12–12, 2020.

Tags: Nanomedicine

Kunjachan, Sijumon; Kotb, Shady; Pola, Robert; Pechar, Michal; Kumar, Rajiv; Singh, Bijay; Gremse, Felix; Taleeli, Reza; Trichard, Florian; Motto-Ros, Vincent; others,

Author correction: Selective priming of tumor Blood Vessels by Radiation therapy enhances nanodrug Delivery Journal Article

In: Scientific Reports, vol. 10, no. 1, pp. 15344, 2020.

Tags: Nanomedicine

Singh, Bijay; Yang, Shicheng; Krishna, Apurva; Sridhar, Srinivas

Nanoparticle formulations of poly (ADP-ribose) polymerase inhibitors for cancer therapy Journal Article

In: Frontiers in Chemistry, vol. 8, pp. 594619, 2020.

Tags: Nanomedicine

TANGUTOORI, Shifalika; Sridhar, Srinivas

Nanoparticle drug delivery system and method of treating cancer and neurotrauma Miscellaneous

2020.

Tags: Nanomedicine

Mitra, Ronodeep; Cheng, Ming; O'Neil, Gerard; Kulkarni, Praveen; Kumar, Rajiv; Sridhar, Srinivas; Ferris, Craig; Hamilton, James; Jo, Hanjoong; Ebong, Eno E

In Vivo Flow-Regulated Endothelial Glycocalyx Integrity Leveraged for Targeted Intravenous Nanoparticle Delivery Proceedings Article

In: 2020 Virtual AIChE Annual Meeting, AIChE 2020.

Tags: Nanomedicine

Cheng, Ming J; Mitra, Ronodeep; Okorafor, Chinedu C; Nersesyan, Alina A; Harding, Ian C; Bal, Nandita N; Kumar, Rajiv; Jo, Hanjoong; Sridhar, Srinivas; Ebong, Eno E

Targeted intravenous nanoparticle delivery: role of flow and endothelial glycocalyx integrity Journal Article

In: Annals of biomedical engineering, vol. 48, pp. 1941–1954, 2020.

Tags: Nanomedicine

Cheng, Ming J; Bal, Nandita N; Prabakaran, Priya; Kumar, Rajiv; Webster, Thomas J; Sridhar, Srinivas; Ebong, Eno E

Ultrasmall gold nanorods: synthesis and glycocalyx-related permeability in human endothelial cells Journal Article

In: International journal of nanomedicine, vol. 14, pp. 319, 2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders W; Medina, Jamie Edward; McCarthy, Eric Timothy; Dinulescu, Daniela M; Sridhar, Srinivas

Nanoformulation of talazoparib delays tumor progression and ascites formation in a late stage cancer model Journal Article

In: Frontiers in oncology, vol. 9, pp. 353, 2019.

Abstract | Tags: Nanomedicine

Versek, Craig; Rissmiller, Armen; Tran, Anthony; Taya, Munish; Chowdhury, Kaushik; Bex, Peter; Sridhar, Srinivas

Portable system for neuro-optical diagnostics using virtual reality display Journal Article

In: Military medicine, vol. 184, no. Supplement_1, pp. 584–592, 2019.

Abstract | Tags: Nanomedicine

Kelada, Olivia J; Kunjachan, Sijumon; Virani, Needa A; Detappe, Alexandre; Hayashi, Jennifer; Ireland, Thomas; Biancur, Douglas E; Kumar, Rajiv; Sridhar, Srinivas; Makrigiorgos, Mike; others,

Noninvasive imaging of tumor hypoxia during radiation-induced tumor vascular disruption Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Orriols, Adrienne; Sridhar, Srinivas

Combination nanotherapy using the PARP inhibitor talazoparib and cyclin dependent kinase inhibitor dinaciclib Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Singh, Bijay; Abdelhalim, Mostafa; Warrington, Stephanee; Sridhar, Srinivas

Development of targeted nanoformulation of talazoparib for combined chemoradiation therapy in lung cancer Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Zhang, Paige Baldwin Di; Leal, Ana S; Carapellucci, Sarah; Sridhar, Srinivas; Liby, Karen T

A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice Journal Article

In: Theranostics, vol. 9, no. 21, pp. 6224, 2019.

Abstract | Tags: Nanomedicine

Bal, Nandita; Cheng, Ming; Kumar, Rajiv; Sridhar, Srinivas; Ebong, Eno E

In Vivo Endothelial Uptake of Nanoparticles: Impact of Disturbed Flow and Degraded Glycocalyx Proceedings Article

In: 2019 AIChE Annual Meeting, AIChE 2019.

Abstract | Tags: Nanomedicine

Kunjachan, Sijumon; Kotb, Shady; Pola, Robert; Pechar, Michal; Kumar, Rajiv; Singh, Bijay; Gremse, Felix; Taleeli, Reza; Trichard, Florian; Motto-Ros, Vincent; others,

Selective priming of tumor Blood Vessels by Radiation therapy enhances nanodrug Delivery Journal Article

In: Scientific reports, vol. 9, no. 1, pp. 1–14, 2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Medina, Jamie; Dinulescu, Daniela; Sridhar, Srinivas

Abstract NT-087: NANOFORMULATION OF TALAZOPARIB SUPPRESSES TUMOR GROWTH AND ASCITES IN A DISSEMINATED CANCER MODEL Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Likhotvorik, Rostislav; Baig, Nabeela; Cropper, Jodie; Carlson, Ruth; Kurmasheva, Raushan; Sridhar, Srinivas

Nanoformulation of talazoparib increases maximum tolerated doses in combination with temozolomide for treatment of Ewing sarcoma Journal Article

In: Frontiers in Oncology, vol. 9, pp. 1416, 2019.

Abstract | Tags: Nanomedicine

Singh, Bijay; Yang, Shicheng; Baldwin, Paige; van de Ven, Anne; Sridhar, Srinivas

Abstract A104: Nanoformulations of PARP and CDK inhibitors for cancer therapy Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Medina, Jamie; Dinulescu, Daniela; Sridhar, Srinivas

NANOFORMULATION OF TALAZOPARIB SUPPRESSES TUMOR GROWTH AND ASCITES IN A DISSEMINATED CANCER MODEL Proceedings Article

In: CLINICAL CANCER RESEARCH, pp. 198–198, AMER ASSOC CANCER RESEARCH 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA~… 2019.

Abstract | Tags: Nanomedicine

Cheng, Ming J; Prabakaran, Priya; Kumar, Rajiv; Sridhar, Srinivas; Ebong, Eno E

Synthesis of functionalized 10-nm polymer-coated gold particles for endothelium targeting and drug delivery Journal Article

In: JoVE (Journal of Visualized Experiments), no. 131, pp. e56760, 2018.

Abstract | Tags: Nanomedicine

Gharagouzloo, Codi A; Timms, Liam; Qiao, Ju; Fang, Zihang; Nneji, Joseph; Pandya, Aniket; Kulkarni, Praveen; van de Ven, Anne L; Ferris, Craig; Sridhar, Srinivas

Dataset on a 173 region awake resting state quantitative cerebral blood volume rat brain atlas and regional changes to cerebral blood volume under isoflurane anesthetization and CO2 challenge Journal Article

In: Data in brief, vol. 17, pp. 393–396, 2018.

Tags: Nanomedicine

Kunjachan, Sijumon; Kotb, Shady; Kumar, Rajiv; Pola, Robert; Pechar, Michal; Gremse, Felix; Taleeli, Reza; Trichard, Florian; Motto-Ros, Vincent; Sancey, Lucie; others,

Targeted Drug Delivery by Radiation-Induced Tumor Vascular Modulation Journal Article

In: bioRxiv, pp. 268714, 2018.

Abstract | Tags: Nanomedicine

Gupta, Parul; Singh, Manjri; Kumar, Rajiv; Belz, Jodi; Shanker, Rishi; Dwivedi, Premendra D; Sridhar, Srinivas; Singh, Surinder P

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 67, 2018.

Abstract | Tags: Nanomedicine

Baronia, Richa; Singh, Manjri; Gupta, Rajat B; Karuppiah, Stalin; Kumar, Rajiv; Belz, Jodi; Shanker, Rishi; Sridhar, Srinivas; Singh, Surinder P

Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 113, 2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Tangutoori, Shifalika; Sridhar, Srinivas

In vitro analysis of pArp inhibitor nanoformulations Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 59, 2018.

Abstract | Tags: Nanomedicine

Upponi, Jaydev R; Jerajani, Kaushal; Nagesha, Dattatri K; Kulkarni, Praveen; Sridhar, Srinivas; Ferris, Craig; Torchilin, Vladimir P

Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents Journal Article

In: Biomaterials, vol. 170, pp. 26–36, 2018.

Abstract | Tags: Nanomedicine

Versek, C; Frasca, T; Zhou, J; Chowdhury, K; Sridhar, S

Electric field encephalography for brain activity monitoring Journal Article

In: Journal of neural engineering, vol. 15, no. 4, pp. 046027, 2018.

Abstract | Tags: Nanomedicine, Opthalmology

Thanh, Nguyen; Phuc, Xuan; Sridhar, Srinivas

Nanoscale Magnetism in Next Generation Magnetic Nanoparticles Technical Report

UNIVERSITY COLLEGE LONDON London United Kingdom 2018.

Abstract | Tags: MRI, Nanomedicine

Guthier, CV; D'Amico, AV; King, MT; Nguyen, PL; Orio, PF; Sridhar, S; Makrigiorgos, GM; Cormack, RA

Determining optimal eluter design by modeling physical dose enhancement in brachytherapy Journal Article

In: Medical physics, vol. 45, no. 8, pp. 3916–3925, 2018.

Abstract | Tags: Nanomedicine

Vazquez-Pagan, Ana G; Baldwin, Paige; Ashtaputre, Ravina M; Kunjachan, Sijumon; Sridhar, Srinivas; Kumar, Rajiv; Berbeco, Ross

Nanoparticle-mediated concomitant radiation dose amplification and PARP inhibition in lung cancer Miscellaneous

2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Kumar, Rajiv; Sridhar, Srinivas

Targeted nanotherapy using the PARP inhibitor talazoparib for breast cancer treatment Miscellaneous

2018.

Abstract | Tags: Nanomedicine

Kunjachan, S; Kotb, S; Kumar, R; Pola, R; Pechar, M; Gremse, F; Taleei, R; Trichard, F; Motto-Ros, V; Sancey, L; others,

BEST IN PHYSICS (THERAPY): Enhanced Drug Delivery by Nanoparticle and Radiation-Mediated Tumor Vascular Modulation Proceedings Article

In: MEDICAL PHYSICS, pp. E535–E535, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 2018.

Tags: Nanomedicine

Zhang, Di; Baldwin, Paige; Sridhar, Srinivas; Liby, Karen

Nanoformulated Talazoparib enhances the efficacy and reduces the toxicity of this PARP inhibitor in a preclinical model of BRCA-deficient breast cancer Journal Article

In: The FASEB Journal, vol. 32, no. 1_supplement, pp. 565–10, 2018.

Abstract | Tags: Nanomedicine

Mitra, Ronodeep; Qiao, Ju; Madhavan, Sudharsan; O’Neil, Gerard L; Ritchie, Bailey; Kulkarni, Praveen; Sridhar, Srinivas; van de Ven, Anne L; Kemmerling, Erica Cherry M; Ferris, Craig; others,

The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation Journal Article

In: Translational medicine communications, vol. 3, no. 1, pp. 1–15, 2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders W; Tangutoori, Shifalika; Dinulescu, Daniela M; Sridhar, Srinivas

Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment Journal Article

In: International journal of nanomedicine, vol. 13, pp. 8063, 2018.

Abstract | Tags: Nanomedicine

Zhang, Di; Baldwin, Paige; Sridhar, Srinivas; Liby, Karen

Developing a nanoformulation of the PARP inhibitor talazoparib as a novel delivery for treatment of BRCA-deficient breast cancer Miscellaneous

2018.

Abstract | Tags: Nanomedicine

Wilfred, NGWA; Kumar, Rajiv; Makrigiorgos, Gerassimos; Sridhar, Srinivas; Dougan, Stephanie

Biomaterials for combined radiotherapy and immunotherapy of cancer Miscellaneous

2018, (US Patent App. 15/752,099).

Abstract | Tags: Nanomedicine