We have developed a novel (patent pending) electric field measurement technology called Electric Field Encephalography (EFEG) for brain signal monitoring. NeuroFieldz technology is comprised of a system of high density array of sensors for measuring and analyzing the electric fields generated by the brain arising from intrinsic activity or external stimuli. The EFEG brain monitoring technique is a new modality that has several advantages over the current modalities, electroencephalography EEG (which measures the electric potential on the scalp) and magnetoencephalography MEG (which measures the magnetic field). Compared with MEG, EFEG has higher spatial resolution, is unaffected by stray magnetic fields, and does not require expensive bulky cryogenic equipment, thus making it field-deployable. Compared with EEG, EFEGTM is reference-less, has higher spatial resolution, leads to increased number of uncorrelated signals, and improves source reconstruction precision.  EFEG also provides dynamical information on millisecond time scales which is much faster than fMRI. The accurate source localization provided by EFEG will be of immense benefit in analyzing and localizing neurological signals (e.g. epileptic), as well as understanding the brains response to external stimuli

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Cheng, Ming J; Mitra, Ronodeep; Okorafor, Chinedu C; Nersesyan, Alina A; Harding, Ian C; Bal, Nandita N; Kumar, Rajiv; Jo, Hanjoong; Sridhar, Srinivas; Ebong, Eno E

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In: Annals of Biomedical Engineering, pp. 1–14, 2020.

Abstract | Tags: Nanomedicine

Cheng, Ming J; Bal, Nandita N; Prabakaran, Priya; Kumar, Rajiv; Webster, Thomas J; Sridhar, Srinivas; Ebong, Eno E

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In: International journal of nanomedicine, vol. 14, pp. 319, 2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders W; Medina, Jamie Edward; McCarthy, Eric Timothy; Dinulescu, Daniela M; Sridhar, Srinivas

Nanoformulation of talazoparib delays tumor progression and ascites formation in a late stage cancer model Journal Article

In: Frontiers in oncology, vol. 9, pp. 353, 2019.

Abstract | Tags: Nanomedicine

Versek, Craig; Rissmiller, Armen; Tran, Anthony; Taya, Munish; Chowdhury, Kaushik; Bex, Peter; Sridhar, Srinivas

Portable system for neuro-optical diagnostics using virtual reality display Journal Article

In: Military medicine, vol. 184, no. Supplement_1, pp. 584–592, 2019.

Abstract | Tags: Nanomedicine

Kelada, Olivia J; Kunjachan, Sijumon; Virani, Needa A; Detappe, Alexandre; Hayashi, Jennifer; Ireland, Thomas; Biancur, Douglas E; Kumar, Rajiv; Sridhar, Srinivas; Makrigiorgos, Mike; others,

Noninvasive imaging of tumor hypoxia during radiation-induced tumor vascular disruption Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Orriols, Adrienne; Sridhar, Srinivas

Combination nanotherapy using the PARP inhibitor talazoparib and cyclin dependent kinase inhibitor dinaciclib Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Singh, Bijay; Abdelhalim, Mostafa; Warrington, Stephanee; Sridhar, Srinivas

Development of targeted nanoformulation of talazoparib for combined chemoradiation therapy in lung cancer Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Zhang, Paige Baldwin Di; Leal, Ana S; Carapellucci, Sarah; Sridhar, Srinivas; Liby, Karen T

A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice Journal Article

In: Theranostics, vol. 9, no. 21, pp. 6224, 2019.

Abstract | Tags: Nanomedicine

Bal, Nandita; Cheng, Ming; Kumar, Rajiv; Sridhar, Srinivas; Ebong, Eno E

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In: 2019 AIChE Annual Meeting, AIChE 2019.

Abstract | Tags: Nanomedicine

Kunjachan, Sijumon; Kotb, Shady; Pola, Robert; Pechar, Michal; Kumar, Rajiv; Singh, Bijay; Gremse, Felix; Taleeli, Reza; Trichard, Florian; Motto-Ros, Vincent; others,

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In: Scientific reports, vol. 9, no. 1, pp. 1–14, 2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Medina, Jamie; Dinulescu, Daniela; Sridhar, Srinivas

Abstract NT-087: NANOFORMULATION OF TALAZOPARIB SUPPRESSES TUMOR GROWTH AND ASCITES IN A DISSEMINATED CANCER MODEL Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Likhotvorik, Rostislav; Baig, Nabeela; Cropper, Jodie; Carlson, Ruth; Kurmasheva, Raushan; Sridhar, Srinivas

Nanoformulation of talazoparib increases maximum tolerated doses in combination with temozolomide for treatment of Ewing sarcoma Journal Article

In: Frontiers in Oncology, vol. 9, pp. 1416, 2019.

Abstract | Tags: Nanomedicine

Singh, Bijay; Yang, Shicheng; Baldwin, Paige; van de Ven, Anne; Sridhar, Srinivas

Abstract A104: Nanoformulations of PARP and CDK inhibitors for cancer therapy Miscellaneous

2019.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Medina, Jamie; Dinulescu, Daniela; Sridhar, Srinivas

NANOFORMULATION OF TALAZOPARIB SUPPRESSES TUMOR GROWTH AND ASCITES IN A DISSEMINATED CANCER MODEL Inproceedings

In: CLINICAL CANCER RESEARCH, pp. 198–198, AMER ASSOC CANCER RESEARCH 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA~… 2019.

Abstract | Tags: Nanomedicine

Cheng, Ming J; Prabakaran, Priya; Kumar, Rajiv; Sridhar, Srinivas; Ebong, Eno E

Synthesis of functionalized 10-nm polymer-coated gold particles for endothelium targeting and drug delivery Journal Article

In: JoVE (Journal of Visualized Experiments), no. 131, pp. e56760, 2018.

Abstract | Tags: Nanomedicine

Gharagouzloo, Codi A; Timms, Liam; Qiao, Ju; Fang, Zihang; Nneji, Joseph; Pandya, Aniket; Kulkarni, Praveen; van de Ven, Anne L; Ferris, Craig; Sridhar, Srinivas

Dataset on a 173 region awake resting state quantitative cerebral blood volume rat brain atlas and regional changes to cerebral blood volume under isoflurane anesthetization and CO2 challenge Journal Article

In: Data in brief, vol. 17, pp. 393–396, 2018.

Tags: Nanomedicine

Kunjachan, Sijumon; Kotb, Shady; Kumar, Rajiv; Pola, Robert; Pechar, Michal; Gremse, Felix; Taleeli, Reza; Trichard, Florian; Motto-Ros, Vincent; Sancey, Lucie; others,

Targeted Drug Delivery by Radiation-Induced Tumor Vascular Modulation Journal Article

In: bioRxiv, pp. 268714, 2018.

Abstract | Tags: Nanomedicine

Celluzzi, Antonella; Paolini, Alessandro; D’Oria, Valentina; Risoluti, Roberta; Materazzi, Stefano; Pezzullo, Marco; Casciardi, Stefano; Sennato, Simona; Bordi, Federico; Masotti, Andrea

Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells Journal Article

In: International journal of nanomedicine, vol. 13, pp. 1, 2018.

Abstract | Tags: Nanomedicine

Gupta, Parul; Singh, Manjri; Kumar, Rajiv; Belz, Jodi; Shanker, Rishi; Dwivedi, Premendra D; Sridhar, Srinivas; Singh, Surinder P

Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 67, 2018.

Abstract | Tags: Nanomedicine

Baronia, Richa; Singh, Manjri; Gupta, Rajat B; Karuppiah, Stalin; Kumar, Rajiv; Belz, Jodi; Shanker, Rishi; Sridhar, Srinivas; Singh, Surinder P

Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 113, 2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Tangutoori, Shifalika; Sridhar, Srinivas

In vitro analysis of pArp inhibitor nanoformulations Journal Article

In: International journal of nanomedicine, vol. 13, no. T-NANO 2014 Abstracts, pp. 59, 2018.

Abstract | Tags: Nanomedicine

Upponi, Jaydev R; Jerajani, Kaushal; Nagesha, Dattatri K; Kulkarni, Praveen; Sridhar, Srinivas; Ferris, Craig; Torchilin, Vladimir P

Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents Journal Article

In: Biomaterials, vol. 170, pp. 26–36, 2018.

Abstract | Tags: Nanomedicine

Versek, C; Frasca, T; Zhou, J; Chowdhury, K; Sridhar, S

Electric field encephalography for brain activity monitoring Journal Article

In: Journal of neural engineering, vol. 15, no. 4, pp. 046027, 2018.

Abstract | Tags: Nanomedicine, Opthalmology

Thanh, Nguyen; Phuc, Xuan; Sridhar, Srinivas

Nanoscale Magnetism in Next Generation Magnetic Nanoparticles Technical Report

UNIVERSITY COLLEGE LONDON London United Kingdom 2018.

Abstract | Tags: MRI, Nanomedicine

Guthier, CV; D'Amico, AV; King, MT; Nguyen, PL; Orio, PF; Sridhar, S; Makrigiorgos, GM; Cormack, RA

Determining optimal eluter design by modeling physical dose enhancement in brachytherapy Journal Article

In: Medical physics, vol. 45, no. 8, pp. 3916–3925, 2018.

Abstract | Tags: Nanomedicine

Amutha, S; Sridhar, S

Green synthesis of magnetic iron oxide nanoparticle using leaves of Glycosmis mauritiana and their antibacterial activity against human pathogens Journal Article

In: Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 5, pp. 22–26, 2018.

Abstract | Tags: Nanomedicine

Vazquez-Pagan, Ana G; Baldwin, Paige; Ashtaputre, Ravina M; Kunjachan, Sijumon; Sridhar, Srinivas; Kumar, Rajiv; Berbeco, Ross

Nanoparticle-mediated concomitant radiation dose amplification and PARP inhibition in lung cancer Miscellaneous

2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Kumar, Rajiv; Sridhar, Srinivas

Targeted nanotherapy using the PARP inhibitor talazoparib for breast cancer treatment Miscellaneous

2018.

Abstract | Tags: Nanomedicine

Kunjachan, S; Kotb, S; Kumar, R; Pola, R; Pechar, M; Gremse, F; Taleei, R; Trichard, F; Motto-Ros, V; Sancey, L; others,

BEST IN PHYSICS (THERAPY): Enhanced Drug Delivery by Nanoparticle and Radiation-Mediated Tumor Vascular Modulation Inproceedings

In: MEDICAL PHYSICS, pp. E535–E535, WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 2018.

Tags: Nanomedicine

Zhang, Di; Baldwin, Paige; Sridhar, Srinivas; Liby, Karen

Nanoformulated Talazoparib enhances the efficacy and reduces the toxicity of this PARP inhibitor in a preclinical model of BRCA-deficient breast cancer Journal Article

In: The FASEB Journal, vol. 32, no. 1_supplement, pp. 565–10, 2018.

Abstract | Tags: Nanomedicine

Mitra, Ronodeep; Qiao, Ju; Madhavan, Sudharsan; O’Neil, Gerard L; Ritchie, Bailey; Kulkarni, Praveen; Sridhar, Srinivas; van de Ven, Anne L; Kemmerling, Erica Cherry M; Ferris, Craig; others,

The comparative effects of high fat diet or disturbed blood flow on glycocalyx integrity and vascular inflammation Journal Article

In: Translational medicine communications, vol. 3, no. 1, pp. 1–15, 2018.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders W; Tangutoori, Shifalika; Dinulescu, Daniela M; Sridhar, Srinivas

Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment Journal Article

In: International journal of nanomedicine, vol. 13, pp. 8063, 2018.

Abstract | Tags: Nanomedicine

Wilfred, NGWA; Kumar, Rajiv; Makrigiorgos, Gerassimos; Sridhar, Srinivas; Dougan, Stephanie

Biomaterials for combined radiotherapy and immunotherapy of cancer Miscellaneous

2018, (US Patent App. 15/752,099).

Abstract | Tags: Nanomedicine

Geilich, Benjamin M; Gelfat, Ilia; Sridhar, Srinivas; van de Ven, Anne L; Webster, Thomas J

Superparamagnetic iron oxide-encapsulating polymersome nanocarriers for biofilm eradication Journal Article

In: Biomaterials, vol. 119, pp. 78–85, 2017.

Abstract | Tags: Nanomedicine

Paro, Autumn D; Shanmugam, Ilan; van de Ven, Anne; Kumar, Rajiv; Webster, Thomas J; Sridhar, Srinivas

Abstract B44: Biological mechanisms involved in nanoparticle-enhanced radiation therapy for pancreatic cancer Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Belz, Jodi; Thong, Jeremy; Ojo, Noelle Castilla; Liby, Karen; Dinulescu, Daniela; Sridhar, Srinivas

Abstract B29: Nanoformulations and sustained delivery systems for the PARP inhibitors Olaparib and Talazoparib Miscellaneous

2017.

Abstract | Tags: Nanomedicine

van de Ven, Anne L; Tangutoori, Shifalika; Baldwin, Paige; Qiao, Ju; Gharagouzloo, Codi; Seitzer, Nina; Clohessy, John; Korideck, Houari; Makrigiorgos, Mike G; Cormack, Robert; others,

Abstract B48: Prostate cancer pre-treatment with nanoformulated Olaparib overcomes radiation resistance Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Kumar, Rajiv; Ngwa, Wilfred; Joshi, Vinit; Kunjachan, Sijumon; Berbeco, Ross; Makrigiorgos, Mike; Sridhar, Srinivas

Abstract B41: Gold nanoparticles based platforms for localized radiosensitization in cancer radiation therapy Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Belz, Jodi; Ojo, Noelle Castilla; Baldwin, Paige; Kumar, Rajiv; van de Ven, Anne; Liby, Karen; Cormack, Robert; Makrigiorgos, Mike; Sridhar, Srinivas

Abstract B30: Sustained release of PARP inhibitor Talazoparib and chemotherapeutic Docetaxel from modified brachytherapy spacers for treatment of breast and prostate cancer Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Belz, Jodi; Castilla-Ojo, Noelle; Sridhar, Srinivas; Kumar, Rajiv

Radiosensitizing silica nanoparticles encapsulating docetaxel for treatment of prostate cancer Incollection

In: Cancer Nanotechnology, pp. 403–409, Humana Press, New York, NY, 2017.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Tangutoori, Shifalika; Sridhar, Srinivas

Generation of Dose--Response Curves and Improved IC50s for PARP Inhibitor Nanoformulations Incollection

In: Cancer Nanotechnology, pp. 337–342, Humana Press, New York, NY, 2017.

Tags: Nanomedicine

Guthier, Christian V; D'Amico, Anthony V; King, Martin T; Nguyen, Paul L; Orio, Peter F; Sridhar, Srinivas; Makrigiorgos, Mike G; Cormack, Robert A

Focal Radiosensitization of Brachytherapy: Determining the Optimal Design of Drug Eluting Implants Journal Article

In: Brachytherapy, vol. 16, no. 3, pp. S115, 2017.

Abstract | Tags: Nanomedicine

van de Ven, Anne L; Tangutoori, Shifalika; Baldwin, Paige; Qiao, Ju; Gharagouzloo, Codi; Seitzer, Nina; Clohessy, John G; Makrigiorgos, Mike G; Cormack, Robert; Pandolfi, Pier Paolo; others,

Nanoformulation of olaparib amplifies PARP inhibition and sensitizes PTEN/TP53-deficient prostate cancer to radiation Journal Article

In: Molecular cancer therapeutics, vol. 16, no. 7, pp. 1279–1289, 2017.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Ohman, Anders; Dinulescu, Daniela; Sridhar, Srinivas

Abstract NTOC-080: NANOOLAPARIB: AN INTRAPERITONEAL PARP INHIBITOR THERAPY FOR OVARIAN CANCER Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Baldwin, Paige; Kumar, Rajiv; Favours, Edward; Liby, Karen; Kurmasheva, Raushan; Kozono, David; Sridhar, Srinivas

Nanoformulated Talazoparib and Olaparib for enhanced delivery Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Baig, Nabeela; Likhotvorik, Rostislav; Baldwin, Paige; Sridhar, Srinivas; Kurmasheva, Raushan

Nanoformulation of talazoparib to increase efficacy when combined with temozolomide for the treatment of Ewing sarcoma xenografts Miscellaneous

2017.

Abstract | Tags: Nanomedicine

Hachani, Roxanne; Birchall, Martin A; Lowdell, Mark W; Kasparis, Georgios; Tung, Le D; Manshian, Bella B; Soenen, Stefaan J; Gsell, Willy; Himmelreich, Uwe; Gharagouzloo, Codi A; others,

Assessing cell-nanoparticle interactions by high content imaging of biocompatible iron oxide nanoparticles as potential contrast agents for magnetic resonance imaging Journal Article

In: Scientific reports, vol. 7, no. 1, pp. 1–14, 2017.

Abstract | Tags: Nanomedicine

Belz, Jodi E; Kumar, Rajiv; Baldwin, Paige; Ojo, Noelle Castilla; Leal, Ana S; Royce, Darlene B; Zhang, Di; van de Ven, Anne L; Liby, Karen T; Sridhar, Srinivas

Sustained release talazoparib implants for localized treatment of BRCA1-deficient breast cancer Journal Article

In: Theranostics, vol. 7, no. 17, pp. 4340, 2017.

Abstract | Tags: Nanomedicine

Belz, Jodi; Ojo, Noelle Castilla; Baldwin, Paige; Kumar, Rajiv; van de Ven, Anne; Liby, Karen; Cormack, Robert; Makrigiorgos, Mike; Sridhar, Srinivas

Sustained release of PARP inhibitor Talazoparib and chemotherapeutic Docetaxel from modified brachytherapy spacers for treatment of breast and prostate cancer Inproceedings

In: CANCER RESEARCH, AMER ASSOC CANCER RESEARCH 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA~… 2017.

Abstract | Tags: Nanomedicine

Barlow, Jacob; Gozzi, Kevin; Kelley, Chase P; Geilich, Benjamin M; Webster, Thomas J; Chai, Yunrong; Sridhar, Srinivas; van de Ven, Anne L

High throughput microencapsulation of Bacillus subtilis in semi-permeable biodegradable polymersomes for selenium remediation Journal Article

In: Applied microbiology and biotechnology, vol. 101, no. 1, pp. 455–464, 2017.

Tags: Nanomedicine