Srinivas Sridhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

See Google patents for the latest list of granted and pending patents

Patents issued

Sensor system and process for measuring electric activity of the brain, …

WO EP US JP US10912480B2 Srinivas Sridhar Northeastern University

Priority 2013-06-21 • Filed 2014-06-20 • Granted 2021-02-09 • Published 2021-02-09

A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK AU2016305473B2 Srinivas Sridhar Dana-Farber Cancer Institute, Inc.

Priority 2015-08-13 • Filed 2016-08-15 • Granted 2021-08-19 • Published 2021-08-19

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP EP3038600B1 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Granted 2020-06-03 • Published 2020-06-03

A nanoparticulate formulation of an inhibitor of a poly (ADP-ribose) polymerase (PARP) enzyme, the formulation comprising a suspension of lipid vesicles in an aqueous medium, wherein the lipid vesicles have a positive surface charge, have an average diameter in the range from about 50 nm to about …

Electric field encephalography: electric field based brain signal detection and …

WO EP US US11083401B2 Srinivas Sridhar Northeastern University

Priority 2012-08-09 • Filed 2012-08-09 • Granted 2021-08-10 • Published 2021-08-10

Systems and methods for measuring brain activity of a subject are disclosed, comprising: positioning a plurality of electric field sensors at multiple positions on the exterior of a skull of the subject; measuring one to three components of a plurality of instantaneous electric field vectors …

Photonic crystal devices using negative refraction

WO US US7808716B2 Srinivas Sridhar Northeastern University

Priority 2005-05-16 • Filed 2006-05-16 • Granted 2010-10-05 • Published 2010-10-05

Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also …

Biopolymer-nanoparticle composite implant for tumor cell tracking

WO EP US CA US10799604B2 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Granted 2020-10-13 • Published 2020-10-13

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor …

Sensor system utilizing piezoelectric microcantilever coupled with resonating …

WO US US9921226B2 Srinivas Sridhar Northeastern University

Priority 2013-04-08 • Filed 2014-04-08 • Granted 2018-03-20 • Published 2018-03-20

An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source …

Patent Applications and Pending

Anisotropic metal-dielectric metamaterials for broadband all-angle negative …

US US20090040132A1 Srinivas Sridhar Northeastern University

Priority 2007-07-24 • Filed 2008-07-24 • Published 2009-02-12

A metamaterial comprises a plurality of metallic nanowires embedded in a dielectric matrix. The metamaterial composite media provide broadband all-angle negative refraction and flat lens, superlens and curved hyperlens imaging in specific spectral regions over a wide range of frequencies including …

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP US10111871B2 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Granted 2018-10-30 • Published 2018-10-30

The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the …

Electric field encephalography: electric field based brain signal detection and …

WO EP US US20160081577A1 Srinivas Sridhar Northeastern University

Priority 2012-08-09 • Filed 2012-08-09 • Published 2016-03-24

Systems and methods for measuring brain activity of a subject are disclosed, comprising: positioning a plurality of electric field sensors at multiple positions on the exterior of a skull of the subject; measuring one to three components of a plurality of instantaneous electric field vectors …

Sensor system and process for measuring electric activity of the brain, …

WO EP US JP EP3010408A2 Srinivas Sridhar Northeastern University

Priority 2013-06-21 • Filed 2014-06-20 • Published 2016-04-27

A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an …

Sensor system and process for measuring electric activity of the brain, …

WO EP US JP WO2014205356A2 Sridhar SRINIVAS Northeastern University

Priority 2013-06-21 • Filed 2014-06-20 • Published 2014-12-24

A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an …

Sensor system and process for measuring electric activity of the brain, …

WO EP US JP EP3010408A4 Srinivas Sridhar Northeastern University

Priority 2013-06-21 • Filed 2014-06-20 • Published 2017-02-22

Quantitative magnetic resonance imaging of the vasculature

WO EP US EP3325992A1 Srinivas Sridhar Northeastern University

Priority 2015-07-24 • Filed 2016-06-09 • Published 2018-05-30

2.1 Methods All animal experiments were conducted in accordance with the Northeastern University Division of Laboratory Animal Medicine and Institutional Animal Care and Use Committee. MRI images were obtained at ambient temperature (~25°C) using a Bruker Biospec 7.0T/20-cm USR horizontal magnet ( …

Quantitative Magnetic Resonance Imaging of the Vasculature

WO EP US US20190246938A1 Srinivas Sridhar Northeastern University

Priority 2015-07-24 • Filed 2016-06-09 • Published 2019-08-15

1.3 Quantification of Blood Pool Ferumoxytol In Vivo All animal experiments were conducted in accordance with the Northeastern University Division of Laboratory Animal Medicine and Institutional Animal Care and Use Committee. QUTE-CE was used to measure the concentration of ferumoxytol in the blood …

Quantitative magnetic resonance imaging of the vasculature

WO EP US WO2017019182A1 Srinivas Sridhar Northeastern University

Priority 2015-07-24 • Filed 2016-06-09 • Published 2017-02-02

2.1 Methods All animal experiments were conducted in accordance with the Northeastern University Division of Laboratory Animal Medicine and Institutional Animal Care and Use Committee. MRI images were obtained at ambient temperature (~25°C) using a Bruker Biospec 7.0T/20-cm USR horizontal magnet ( …

Magnetic Nanoplatforms for Theranostic and Multi-Modal Imaging Applications

WO US US20130323165A1 Srinivas Sridhar Northeastern University

Priority 2010-03-08 • Filed 2011-03-08 • Published 2013-12-05

  1. MRI Imaging with MCL MR imaging was performed on a 7 T preclinical MRI system (BioSpec 70/20USR, Bruker BioSpin Corp., Billerica, Mass.) at the Center for Translational Neuro-Imaging at NortheasternUniversity. A whole body quadrature coil was used for reception and emission. Healthy mice A …

Magnetic nanoplatforms for theranostic and multi-modal imaging applications

WO US WO2011112597A1 Srinivas Sridhar Northeastern University

Priority 2010-03-08 • Filed 2011-03-08 • Published 2011-09-15

  1. MRI Imaging With MCL |0104] MR imaging was performed on a 7 T preclinical MRI system (BioSpec 70/20USR, Bruker BioSpin Corp., Billerica, MA) at the Center for Translational Neuro-Imaging at NortheasternUniversity. A whole body quadrature coil was used for reception and emission. A. Healthy …

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP EP3038600A1 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Published 2016-07-06

The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the …

Photonic Crystal Devices Using Negative Refraction

WO US US20090086322A1 Srinivas Sridhar Northeastern University

Priority 2005-05-16 • Filed 2006-05-16 • Published 2009-04-02

Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK AU2016305473A8 Srinivas Sridhar Dana-Farber Cancer Institute, Inc.

Priority 2015-08-13 • Filed 2016-08-15 • Published 2019-07-25

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK EP3334460A1 Srinivas Sridhar Northeastern University

Priority 2015-08-13 • Filed 2016-08-15 • Published 2018-06-20

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP EP3038600A4 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Published 2017-03-01

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK EP3334460A4 Srinivas Sridhar Northeastern University

Priority 2015-08-13 • Filed 2016-08-15 • Published 2019-04-03

Quantitative magnetic resonance imaging of the vasculature

WO EP US EP3325992A4 Srinivas Sridhar Northeastern University

Priority 2015-07-24 • Filed 2016-06-09 • Published 2019-03-27

Sensor system for measuring brain electric activity

WO EP US JP WO2014205356A3 Sridhar SRINIVAS Northeastern University

Priority 2013-06-21 • Filed 2014-06-20 • Published 2015-02-19

A sensor system and process for measuring electromagnetic activity of a brain are provided. The system and process employ a sensor assembly having a plurality of electrodes arranged in a closely spaced arrangement and a processor to determine a weighted average of the signals indicative of an …

Biopolymer-nanoparticle composite implant for tumor cell tracking

WO EP US CA EP3171897A4 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Published 2018-03-21

Biopolymer-nanoparticle composite implant for tumor cell tracking

WO EP US CA EP3171897A1 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Published 2017-05-31

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK US20180271978A1 Srinivas Sridhar Northeastern University

Priority 2015-08-13 • Filed 2016-08-15 • Published 2018-09-27

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Electric field encephalography: electric field based brain signal detection and …

WO EP US EP2882335A1 Srinivas Sridhar Northeastern University

Priority 2012-08-09 • Filed 2012-08-09 • Published 2015-06-17

ELECTRIC FIELD ENCEPHALOGRAPHY: ELECTRIC FIELD BASED BRAIN SIGNAL DETECTION AND MONITORING Field of the Disclosure [0001] This application relates to the field of detection and monitoring of brain signals, and more particularly to detection and monitoring of electric fields generated by the brain.

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP US20160206615A1 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Published 2016-07-21

The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the …

Portable Brain and Vision Diagnostic and Therapeutic System

WO US US20190307350A1 Srinivas Sridhar Northeastern University

Priority 2016-11-02 • Filed 2017-11-02 • Published 2019-10-10

A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK US10835604B2 Srinivas Sridhar Northeastern University

Priority 2015-08-13 • Filed 2016-08-15 • Granted 2020-11-17 • Published 2020-11-17

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK AU2016305473A1 Srinivas Sridhar Dana-Farber Cancer Institute, Inc.

Priority 2015-08-13 • Filed 2016-08-15 • Published 2018-02-08

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Electric field encephalography: electric field based brain signal detection and …

WO EP US EP2882335A4 Srinivas Sridhar Univ Northeastern

Priority 2012-08-09 • Filed 2012-08-09 • Published 2016-04-06

Biopolymer-Nanoparticle Composite Implant for Tumor Cell Tracking

WO EP US CA US20170209601A1 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Published 2017-07-27

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor …

Biopolymer-nanoparticle composite implant for tumor cell tracking

WO EP US CA CA2954725A1 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Published 2016-01-28

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor …

Portable brain and vision diagnostic and therapeutic system

WO US WO2018085598A9 Srinivas Sridhar Northeastern University

Priority 2016-11-02 • Filed 2017-11-02 • Published 2018-09-07

A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) …

Large scale nanoelement assembly method for making nanoscale circuit …

WO US WO2009126952A2 Srinivas Sridhar Northeastern University

Priority 2008-04-11 • Filed 2009-04-13 • Published 2009-10-15

Nanoelements such as single walled carbon nanotubes are assembled in three dimensions into a nanoscale template on a substrate by means of electrophoresis and dielectrophoresis at ambient temperature. The current-voltage relation indicates that strong substrate-nanotube interconnects carrying mA …

Nanoparticle drug delivery system and method of treating cancer and neurotrauma

WO EP US JP WO2015031536A1 Srinivas Sridhar Northeastern University

Priority 2013-08-27 • Filed 2014-08-27 • Published 2015-03-05

The invention provides pharmaceutical formulations of inhibitors for poly (ADP-ribose) polymerase (PARP) enzyme. The formulations can be used in the treatment and prevention of cancer as well as the treatment of neurotrauma and neurodegenerative diseases. The PARP inhibitor is delivered in the …

Large scale nanoelement assembly method for making nanoscale circuit …

WO US US20110024719A1 Srinivas Sridhar Srinivas Sridhar

Priority 2008-04-11 • Filed 2009-04-13 • Published 2011-02-03

Nanoelements such as single walled carbon nanotubes are assembled in three dimensions into a nanoscale template on a substrate by means of electrophoresis and dielectrophoresis at ambient temperature. The current-voltage relation indicates that strong substrate-nanotube interconnects carrying mA …

Portable brain and vision diagnostic and therapeutic system

WO US WO2018085598A1 Srinivas Sridhar Northeastern University

Priority 2016-11-02 • Filed 2017-11-02 • Published 2018-05-11

A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK WO2017027874A8 Srinivas Sridhar Northeastern University

Priority 2015-08-13 • Filed 2016-08-15 • Published 2018-03-22

Compositions and methods for the radiological and immunotherapeutic treatment of cancer are provided. Metallic nanoparticles conjugated with an immunoadjuvant are dispersed within a biodegradable polymer matrix that can be implanted in a patient and released gradually. The implant may be …

Large scale nanoelement assembly method for making nanoscale circuit …

WO US WO2009126952A3 Srinivas Sridhar Northeastern University

Priority 2008-04-11 • Filed 2009-04-13 • Published 2010-01-21

Nanoelements such as single walled carbon nanotubes are assembled in three dimensions into a nanoscale template on a substrate by means of electrophoresis and dielectrophoresis at ambient temperature. The current-voltage relation indicates that strong substrate-nanotube interconnects carrying mA …

Photonic crystal devices using negative refraction

WO US WO2006124962A2 Srinivas Sridhar Northeastern University

Priority 2005-05-16 • Filed 2006-05-16 • Published 2006-11-23

CLAIMSWhat is claimed is : 1. A photonic crystal lens comprising: a body comprised of a photonic crystal material, the body having a planar face and a concave face; the photonic crystal material having a varying permittivity or a varying permeability or a varying permittivity and permeability;

Photonic crystal devices using negative refraction

WO US WO2006124962A3 Srinivas Sridhar Univ Northeastern

Priority 2005-05-16 • Filed 2006-05-16 • Published 2007-04-12

Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses . Demonstration of negative refraction of visible light is also …

Biomaterials for combined radiotherapy and immunotherapy of cancer

WO EP US JP AU CA HK HK1254839A1 Srinivas Sridhar Univ Northeastern

Priority 2015-08-13 • Filed 2018-10-31 • Published 2019-07-26

Electric field encephalography: electric field based brain signal detection and …

WO EP US WO2014025353A1 Srinivas Sridhar Northeastern University

Priority 2012-08-09 • Filed 2012-08-09 • Published 2014-02-13

ELECTRIC FIELD ENCEPHALOGRAPHY: ELECTRIC FIELD BASED BRAIN SIGNAL DETECTION AND MONITORING Field of the Disclosure [0001] This application relates to the field of detection and monitoring of brain signals, and more particularly to detection and monitoring of electric fields generated by the brain.

Biopolymer-nanoparticle composite implant for tumor cell tracking

WO EP US CA WO2016015044A1 Srinivas Sridhar Northeastern University

Priority 2014-07-25 • Filed 2015-07-27 • Published 2016-01-28

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor …

Novel sensor system utilizing piezoelectric microcantilever coupled with …

WO US US20160054329A1 Srinivas Sridhar Northeastern University

Priority 2013-04-08 • Filed 2014-04-08 • Published 2016-02-25

An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source …

A novel sensor system utilizing piezoelectric microcantilever coupled with …

WO US WO2014168924A1 Srinivas Sridhar Northeastern University

Priority 2013-04-08 • Filed 2014-04-08 • Published 2014-10-16

An interchangeable sensor system is described, including: a microcantilever including a beam anchored at a first end, the beam being free to vibrate on another end, wherein a piezoelectric layer is deposited on a surface of the beam; an input configured to receive a voltage from a voltage source …

Nanoencapsulated Combination Drug Formulations

US US20210085619A1 Srinivas Sridhar Northeastern University

Priority 2019-09-23 • Filed 2020-09-23 • Published 2021-03-25

Example 3: Pharmacokinetics and Pharmacodynamics All animal studies were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee (IACUC) at Northeastern University. Pharmacokinetic and pharmacodynamics studies were conducted for each individual formulation …