Publications

@article{yang2024nanomedicine,

title = {Nanomedicine Therapies for Pediatric Diseases},

author = {Shicheng Yang and Kushi Aggarwal and Jillian Jurczyszak and Needa Brown and Srinivas Sridhar},

year  = {2024},

date = {2024-01-01},

journal = {Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology},

volume = {16},

number = {5},

pages = {e1996},

publisher = {John Wiley & Sons, Inc. Hoboken, USA},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{yasmin2024aerosol,

title = {Aerosol delivery of immunotherapy and Hesperetin-loaded nanoparticles increases survival in a murine lung cancer model},

author = {Sayeda Yasmin-Karim and Geraud Richards and Amanda Fam and Alina-Marissa Ogurek and Srinivas Sridhar and G Mike Makrigiorgos},

year  = {2024},

date = {2024-01-01},

journal = {bioRxiv},

pages = {2024–08},

publisher = {Cold Spring Harbor Laboratory},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{timms2024super,

title = {Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI},

author = {Liam Timms and Tianyi Zhou and Ju Qiao and Codi Gharagouzloo and Vishala Mishra and Rita Maria Lahoud and John W Chen and Mukesh Harisinghani and Srinivas Sridhar},

year  = {2024},

date = {2024-01-01},

journal = {International Journal of Biomedical Imaging},

volume = {2024},

number = {1},

pages = {9763364},

publisher = {Hindawi},

keywords = {MRI},

pubstate = {published},

tppubtype = {article}

}

@article{baldwin2024nano,

title = {A nano-cocktail of the PARP inhibitor talazoparib and CDK inhibitor dinaciclib for the treatment of triple negative breast cancer},

author = {Paige Baldwin and Shicheng Yang and Adrienne Orriols and Sherrie Wang and Needa Brown and Srinivas Sridhar},

year  = {2024},

date = {2024-01-01},

journal = {Cancer Nanotechnology},

volume = {15},

number = {1},

pages = {20},

publisher = {Springer Vienna Vienna},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{banijamali2024portable,

title = {Portable multi-focal visual evoked potential diagnostics for multiple sclerosis/optic neuritis patients},

author = {S Mohammad Ali Banijamali and Craig Versek and Kristen Babinski and Sagar Kamarthi and Deborah Green-LaRoche and Srinivas Sridhar},

year  = {2024},

date = {2024-01-01},

journal = {Documenta Ophthalmologica},

volume = {149},

number = {1},

pages = {23–45},

publisher = {Springer Berlin Heidelberg Berlin/Heidelberg},

keywords = {Neurotechnology},

pubstate = {published},

tppubtype = {article}

}

@article{sridhar2023trued,

title = {True superconductivity at near ambient temperature has not been confirmed by Dasenbrock-Gammon et al. Nature, volume 615, pages 244–250 (2023)},

author = {Srinivas Sridhar},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Physics and Chemistry of Solids},

volume = {180},

pages = {111381},

publisher = {Pergamon},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{thong2023esi,

title = {ESI: Multifunctional nanocarriers of Fe3O4@ PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery-Supplementary dataset},

author = {Phan Quoc Thong and Le Thi Thu Huong and Nguyen Dac Tu and Hoang Thi My Nhung and Lam Khanh and Do Hung Manh and Pham Hong Nam and Nguyen Xuan Phuc and Javier Alonso and Ju Qiao and others},

year  = {2023},

date = {2023-01-01},

journal = {(No Title)},

publisher = {Taylor & Francis},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{yang2023sustainedb,

title = {Sustained delivery of PARP inhibitor Talazoparib for the treatment of BRCA-deficient ovarian cancer},

author = {Shicheng Yang and Allen Green and Needa Brown and Alexis Robinson and Merline Senat and Bryanna Testino and Daniela M Dinulescu and Srinivas Sridhar},

year  = {2023},

date = {2023-01-01},

journal = {Frontiers in Oncology},

volume = {13},

pages = {1175617},

publisher = {Frontiers Media SA},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{thong2022multifunctionalb,

title = {Multifunctional nanocarriers of Fe3O4@ PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery},

author = {Phan Quoc Thong and Le Thi Thu Huong and Nguyen Dac Tu and Hoang Thi My Nhung and Lam Khanh and Do Hung Manh and Pham Hong Nam and Nguyen Xuan Phuc and Javier Alonso and Ju Qiao and others},

year  = {2022},

date = {2022-01-01},

journal = {Nanomedicine},

volume = {17},

number = {22},

pages = {1677–1693},

publisher = {Taylor & Francis},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{kunjachan2022retraction,

title = {Retraction Note: Selective Priming of Tumor Blood Vessels by Radiation Therapy Enhances Nanodrug Delivery},

author = {Sijumon Kunjachan and Shady Kotb and Robert Pola and Michal Pechar and Rajiv Kumar and Bijay Singh and Felix Gremse and Reza Taleeli and Florian Trichard and Vincent Motto-Ros and others},

year  = {2022},

date = {2022-01-01},

journal = {Scientific Reports},

volume = {12},

publisher = {Nature Publishing Group},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{cohen2021adapting,

title = {Adapting undergraduate research to remote work to increase engagement},

author = {Susan E Cohen and Sara M Hashmi and A-Andrew D Jones III and Vasiliki Lykourinou and Mary Jo Ondrechen and Srinivas Sridhar and Anne L Ven and Lauren S Waters and Penny J Beuning},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {The Biophysicist},

volume = {2},

number = {2},

pages = {28–32},

publisher = {Biophysical Society},

keywords = {Education},

pubstate = {published},

tppubtype = {article}

}

@article{versek2021portable,

title = {Portable diagnostic system for age-related macular degeneration screening using visual evoked potentials},

author = {Craig Versek and S Mohammad Ali Banijamali and Peter Bex and Kameran Lashkari and Sagar Kamarthi and Srinivas Sridhar},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Eye and brain},

pages = {111–127},

publisher = {Taylor & Francis},

keywords = {Neurotechnology},

pubstate = {published},

tppubtype = {article}

}

@article{timms2021ferumoxytol,

title = {Ferumoxytol-enhanced ultrashort TE MRA and quantitative morphometry of the human kidney vasculature},

author = {Liam Timms and Tianyi Zhou and Yue Lyu and Ju Qiao and Vishala Mishra and Rita Maria Lahoud and Gayatri Veeramani Jayaraman and Andrew S Allegretti and David Drew and Ravi T Seethamraju and others},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Abdominal Radiology},

volume = {46},

pages = {3288–3300},

publisher = {Springer US},

keywords = {MRI},

pubstate = {published},

tppubtype = {article}

}

@article{yang2021recent,

title = {Recent developments in nanomedicine for pediatric cancer},

author = {Shicheng Yang and Mia Wallach and Apurva Krishna and Raushan Kurmasheva and Srinivas Sridhar},

year  = {2021},

date = {2021-01-01},

journal = {Journal of Clinical Medicine},

volume = {10},

number = {7},

pages = {1437},

publisher = {MDPI},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{zhang2021sustained,

title = {Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in BRCA1-deficient mice},

author = {Di Zhang and Bijay Singh and Jessica Moerland and Owen Mitchell and Lizbeth Lockwood and Sarah Carapellucci and Srinivas Sridhar and Karen T Liby},

year  = {2021},

date = {2021-01-01},

journal = {Scientific Reports},

volume = {11},

number = {1},

pages = {1234},

publisher = {Nature Publishing Group UK London},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{rodell2021quantification,

title = {Quantification of cellular drug biodistribution addresses challenges in evaluating in vitro and in vivo encapsulated drug delivery},

author = {Christopher B Rodell and Paige Baldwin and Bianca Fernandez and Ralph Weissleder and Srinivas Sridhar and John Matthew Dubach},

year  = {2021},

date = {2021-01-01},

journal = {Advanced therapeutics},

volume = {4},

number = {3},

pages = {2000125},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{singh2020nanoparticle,

title = {Nanoparticle formulations of poly (ADP-ribose) polymerase inhibitors for cancer therapy},

author = {Bijay Singh and Shicheng Yang and Apurva Krishna and Srinivas Sridhar},

year  = {2020},

date = {2020-01-01},

journal = {Frontiers in Chemistry},

volume = {8},

pages = {594619},

publisher = {Frontiers Media SA},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{kunjachan2020author,

title = {Author correction: Selective priming of tumor Blood Vessels by Radiation therapy enhances nanodrug Delivery},

author = {Sijumon Kunjachan and Shady Kotb and Robert Pola and Michal Pechar and Rajiv Kumar and Bijay Singh and Felix Gremse and Reza Taleeli and Florian Trichard and Vincent Motto-Ros and others},

year  = {2020},

date = {2020-01-01},

journal = {Scientific Reports},

volume = {10},

number = {1},

pages = {15344},

publisher = {Nature Publishing Group UK London},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{zhang2020localized,

title = {Localized delivery of the PARP inhibitor Talazoparib for chemoprevention of breast cancer},

author = {Di Zhang and Bijay Singh and Jessica Moerland and Owen Mitchell and Lizbeth Lockwood and Sarah Carapellucci and Srinivas Sridhar and Karen Liby},

year  = {2020},

date = {2020-01-01},

journal = {Cancer Research},

volume = {80},

number = {16_Supplement},

pages = {12–12},

publisher = {The American Association for Cancer Research},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{mueller2020increased,

title = {Increased carcinoembryonic antigen expression on the surface of lung cancer cells using gold nanoparticles during radiotherapy},

author = {Romy Mueller and Sayeda Yasmin-Karim and Kaylie DeCosmo and Ana Vazquez-Pagan and Srinivas Sridhar and David Kozono and Juergen Hesser and Wilfred Ngwa},

year  = {2020},

date = {2020-01-01},

journal = {Physica Medica},

volume = {76},

pages = {236–242},

publisher = {Elsevier},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{virani2020noninvasive,

title = {Noninvasive imaging of tumor hypoxia after nanoparticle-mediated tumor vascular disruption},

author = {Needa A Virani and Olivia J Kelada and Sijumon Kunjachan and Alexandre Detappe and Jihun Kwon and Jennifer Hayashi and Ana Vazquez-Pagan and Douglas E Biancur and Thomas Ireland and Rajiv Kumar and others},

year  = {2020},

date = {2020-01-01},

journal = {Plos one},

volume = {15},

number = {7},

pages = {e0236245},

publisher = {Public Library of Science San Francisco, CA USA},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{schuemann2020roadmap,

title = {Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions},

author = {Jan Schuemann and Alexander F Bagley and Ross Berbeco and Kyle Bromma and Karl T Butterworth and Hilary L Byrne and B Devika Chithrani and Sang Hyun Cho and Jason R Cook and Vincent Favaudon and others},

year  = {2020},

date = {2020-01-01},

journal = {Physics in Medicine & Biology},

volume = {65},

number = {21},

pages = {21RM02},

publisher = {IOP Publishing},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{mitra2020high,

title = {High fat diet versus disturbed blood flow conditions: Implications for endothelial glycocalyx integrity and pre-atherosclerotic inflammation},

author = {Ronodeep Mitra and Ju Qiao and Sudharsan Madhavan and Gerard O’Neil and Bailey Ritchie and Praveen Kulkarni and Srinivas Sridhar and Anne Ven and Erica Cherry and Craig Ferris and others},

year  = {2020},

date = {2020-01-01},

journal = {The FASEB Journal},

volume = {34},

number = {S1},

pages = {1–1},

publisher = {The Federation of American Societies for Experimental Biology},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{cheng2020targetedb,

title = {Targeted intravenous nanoparticle delivery: role of flow and endothelial glycocalyx integrity},

author = {Ming J Cheng and Ronodeep Mitra and Chinedu C Okorafor and Alina A Nersesyan and Ian C Harding and Nandita N Bal and Rajiv Kumar and Hanjoong Jo and Srinivas Sridhar and Eno E Ebong},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Annals of biomedical engineering},

volume = {48},

pages = {1941–1954},

publisher = {Springer International Publishing},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{versek2020portableb,

title = {Portable Objective Diagnostics using Visual Evoked Potentials for Age-related Macular Degeneration},

author = {Craig Versek and S Mohammad Ali Banijamali and Peter J Bex and Kameran Lashkari and Sagar V Kamarthi and Srinivas Sridhar},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {medRxiv},

pages = {2020–01},

publisher = {Cold Spring Harbor Laboratory Press},

keywords = {Neurotechnology},

pubstate = {published},

tppubtype = {article}

}

@article{cheng2020targeted,

title = {Targeted Intravenous Nanoparticle Delivery: Role of Flow and Endothelial Glycocalyx Integrity},

author = {Ming J Cheng and Ronodeep Mitra and Chinedu C Okorafor and Alina A Nersesyan and Ian C Harding and Nandita N Bal and Rajiv Kumar and Hanjoong Jo and Srinivas Sridhar and Eno E Ebong},

year  = {2020},

date = {2020-01-01},

journal = {Annals of Biomedical Engineering},

pages = {1--14},

abstract = {Therapies for atherosclerotic cardiovascular disease should target early disease stages and specific vascular sites where disease occurs. Endothelial glycocalyx (GCX) degradation compromises endothelial barrier function and increases vascular permeability. This initiates pro-atherosclerotic lipids and inflammatory cells to penetrate vessel walls, and at the same time this can be leveraged for targeted drug delivery. In prior cell culture studies, GCX degradation significantly increased endothelial cell uptake of nanoparticle vehicles that are designed for drug delivery, compared to the effects of intact GCX. The present study assessed if the cell culture findings translate to selective nanoparticle uptake in animal vessels. In mice, the left carotid artery (LCA) was partially ligated to disturb blood flow, which induces GCX degradation, endothelial dysfunction, and atherosclerosis. After ligation, the LCA vessel wall exhibited.},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{versek2020portable,

title = {Portable Objective Diagnostics using Visual Evoked Potentials for Age-related Macular Degeneration},

author = {Craig William Versek and Mohammad Ali S Banijamali and Peter J Bex and Kameran Lashkari and Sagar V Kamarthi and Srinivas Sridhar},

year  = {2020},

date = {2020-01-01},

journal = {medRxiv},

publisher = {Cold Spring Harbor Laboratory Press},

abstract = {Delayed Dark Adapted vision Recovery (DAR) is a biomarker for Age-related Macular Degeneration (AMD); however, its measurement is burdensome for patients and examiners. We developed a portable, wireless, quick-setup system that employs a headset with a smartphone to deliver and analyze controlled dichoptic photobleach and pattern reversal stimuli, and with custom electroencephalography (EEG) electrodes, to measure objective Dark Adapted Visual Evoked Potentials (DAVEP) at multiple locations of the visual field in one comfortable 20-minute session, without requiring subject reporting. DAVEP responses post photobleach (up to 15 minutes), were measured concurrently in both eyes of 13 patients with AMD and 8 others not diagnosed with AMD. New unexpected features were observed in the DAVEP responses at high latencies to scotopic stimulus intensities. The amplitude recovery of the DAVEP response was significantly delayed in AMD patients compared with controls. We developed DAVEP1 scores, a simple metric for DAR, using it to successfully identify all 100% of AMD subjects and correctly classify 90% of subject eyes. Deficits in DAR in patients with AMD can be identified with this objective VEP based system using the DAVEP1 metric, a promising new objective biomarker for this disease that can be easily tested in a clinic.},

keywords = {Neurotechnology, Opthalmology},

pubstate = {published},

tppubtype = {article}

}

@article{baldwin2019nanoformulationb,

title = {Nanoformulation of talazoparib increases maximum tolerated doses in combination with temozolomide for treatment of Ewing sarcoma},

author = {Paige Baldwin and Rostislav Likhotvorik and Nabeela Baig and Jodie Cropper and Ruth Carlson and Raushan Kurmasheva and Srinivas Sridhar},

year  = {2019},

date = {2019-01-01},

journal = {Frontiers in Oncology},

volume = {9},

pages = {1416},

publisher = {Frontiers},

abstract = {The Pediatric Preclinical Testing Program previously identified the PARP inhibitor talazoparib (TLZ) as a means to potentiate temozolomide (TMZ) activity for the treatment of Ewing sarcoma. However, the combination of TLZ and TMZ has been toxic in both preclinical and clinical testing, necessitating TMZ dose reduction to ~15% of the single agent maximum tolerated dose. We have synthesized a nanoparticle formulation of talazoparib (NanoTLZ) to be administered intravenously in an effort to modulate the toxicity profile of this combination treatment. Results in Ewing sarcoma xenograft models are presented to demonstrate the utility of this delivery method both alone and in combination with TMZ. NanoTLZ reduced gross toxicity and had a higher maximum tolerated dose than oral TLZ. The dose of TMZ did not have to be reduced when combined with NanoTLZ as was required when combined with oral TLZ. This indicated the NanoTLZ delivery system may be advantageous in decreasing the systemic toxicity associated with the combination of oral TLZ and TMZ.},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{kunjachan2019selective,

title = {Selective priming of tumor Blood Vessels by Radiation therapy enhances nanodrug Delivery},

author = {Sijumon Kunjachan and Shady Kotb and Robert Pola and Michal Pechar and Rajiv Kumar and Bijay Singh and Felix Gremse and Reza Taleeli and Florian Trichard and Vincent Motto-Ros and others},

year  = {2019},

date = {2019-01-01},

journal = {Scientific reports},

volume = {9},

number = {1},

pages = {1--14},

publisher = {Nature Publishing Group},

abstract = {Effective drug delivery is restricted by pathophysiological barriers in solid tumors. In human pancreatic adenocarcinoma, poorly-permeable blood vessels limit the intratumoral permeation and penetration of chemo or nanotherapeutic drugs. New and clinically viable strategies are urgently sought to breach the neoplastic barriers that prevent effective drug delivery. Here, we present an original idea to boost drug delivery by selectively knocking down the tumor vascular barrier in a human pancreatic cancer model. Clinical radiation activates the tumor endothelial-targeted gold nanoparticles to induce a physical vascular damage due to the high photoelectric interactions. Active modulation of these tumor neovessels lead to distinct changes in tumor vascular permeability. Noninvasive MRI and fluorescence studies, using a short-circulating nanocarrier with MR-sensitive gadolinium and a long-circulating nanocarrier with fluorescence-sensitive nearinfrared dye, demonstrate more than two-fold increase in nanodrug delivery, post tumor vascular modulation. Functional changes in altered tumor blood vessels and its downstream parameters, particularly, changes in Ktrans (permeability), Kep (flux rate), and Ve (extracellular interstitial volume), reflect changes that relate to augmented drug delivery. The proposed dual-targeted therapy effectively invades the tumor vascular barrier and improve nanodrug delivery in a human pancreatic tumor model and it may also be applied to other nonresectable, intransigent tumors that barely respond to standard drug therapies.},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{qiao2019data,

title = {Data on MRI brain lesion segmentation using K-means and Gaussian Mixture Model-Expectation Maximization},

author = {Ju Qiao and Xuezhu Cai and Qian Xiao and Zhengxi Chen and Praveen Kulkarni and Craig Ferris and Sagar Kamarthi and Srinivas Sridhar},

year  = {2019},

date = {2019-01-01},

journal = {Data in brief},

volume = {27},

pages = {104628},

publisher = {Elsevier},

abstract = {The data in this article provide details about MRI lesion segmentation using K-means and Gaussian Mixture Model-Expectation Maximization (GMM-EM) algorithms. Both K-means and GMM-EM algorithms can segment lesion area from the rest of brain MRI automatically. The performance metrics (accuracy, sensitivity, specificity, false positive rate, misclassification rate) were estimated for the algorithms and there was no significant difference between K-means and GMM-EM. In addition, lesion size does not affect the accuracy and sensitivity for either method.},

keywords = {MRI},

pubstate = {published},

tppubtype = {article}

}

@article{di2019nano,

title = {A nano-liposome formulation of the PARP inhibitor Talazoparib enhances treatment efficacy and modulates immune cell populations in mammary tumors of BRCA-deficient mice},

author = {Paige Baldwin Di Zhang and Ana S Leal and Sarah Carapellucci and Srinivas Sridhar and Karen T Liby},

year  = {2019},

date = {2019-01-01},

journal = {Theranostics},

volume = {9},

number = {21},

pages = {6224},

publisher = {Ivyspring International Publisher},

abstract = {Two recently approved PARP inhibitors provide an important new therapeutic option for patients with BRCA-mutated metastatic breast cancer. PARP inhibitors significantly prolong progression-free survival in patients, but conventional oral delivery of PARP inhibitors is hindered by limited bioavailability and off-target toxicities, thus compromising the therapeutic benefits and quality of life for patients. Here, we developed a new delivery system, in which the PARP inhibitor Talazoparib is encapsulated in the bilayer of a nano-liposome, to overcome these limitations.



Methods: Nano-Talazoparib (NanoTLZ) was characterized both in vitro and in vivo. The therapeutic efficacy and toxicity of Nano-Talazoparib (NanoTLZ) were evaluated in BRCA-deficient mice. The regulation of NanoTLZ on gene transcription and immunomodulation were further investigated in spontaneous BRCA-deficient tumors.



Results: NanoTLZ significantly (p<0.05) prolonged the overall survival of BRCA-deficient mice compared to all of the other experimental groups, including saline control, empty nanoparticles, and free Talazoparib groups (oral and i.v.). Moreover, NanoTLZ was better tolerated than treatment with free Talazoparib, with no significant weight lost or alopecia as was observed with the free drug. After 5 doses, NanoTLZ altered the expression of over 140 genes and induced DNA damage, cell cycle arrest and inhibition of cell proliferation in the tumor. In addition, NanoTLZ favorably modulated immune cell populations in vivo and significantly (p<0.05) decreased the percentage of myeloid derived suppressor cells in both the tumor and spleen compared to control groups.



Conclusions: Our results demonstrate that delivering nanoformulated Talazoparib not only enhances treatment efficacy but also reduces off-target toxicities in BRCA-deficient mice; the same potential is predicted for patients with BRCA-deficient breast cancer.



Keywords: PARP inhibitor, Talazoparib, Nanoparticle, BRCA-deficient breast cancer, immunomodulation},

keywords = {Nanomedicine},

pubstate = {published},

tppubtype = {article}

}

@article{sridhar2019portable,

title = {Portable VEP Diagnostics for NeuroVisual Disorders},

author = {Srinivas Sridhar and Craig Versek and Ali Banijamali and Anthony Tran and Armando Cardozo and Kameran Lashkari and Peter Bex},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Investigative Ophthalmology & Visual Science},

volume = {60},

number = {9},

pages = {3591--3591},

publisher = {The Association for Research in Vision and Ophthalmology},

abstract = {Purpose: Visual Evoked Potentials (VEPs) provide objective neuro-opthalmologic assessments that avoid patient task performance but utilizes invasive and cumbersome apparatus. We have developed a system that combines a scalp neuroelectric potential and field sensor with a smartphone in a portable wireless display headset called the NeuroDotVR (Figure 1). The system records VEPs and Fields (VEPF) in response to dichoptic stimuli presented on the smartphone display for a range of neuro-oplthalmologic disorders. We evaluate the NeuroDotVR for Dark Adaptation Recovers (DAR), a key biomarker for age-related macular degeneration (AMD).

Methods: DAR was measured simultaneously in both eyes of# patients with AMD and# age-matched controls. Following a 60s photobleach (400 cd/m 2 white cellphone screen), recovery of visual sensitivity was recorded with VEPFs to pattern reversal checkerboard …},

keywords = {Neurotechnology},

pubstate = {published},

tppubtype = {article}

}